Blue Jays at Astros prediction: Odds, expert picks, starting pitchers, betting trends, and stats for April 21

Its Monday, April 21 and the Blue Jays (12-10) are in Houston to open a series against the Astros (10-11).

Kevin Gausman is slated to take the mound for Toronto against Hunter Brown for Houston.

The Astros fell short of a weekend sweep of the San Diego Padres yesterday falling 3-2. Jake Meyers picked up a couple hits for Houston in the loss.

Toronto lost both games over the weekend to Seattle. Yesterday the Mariners blasted the Jays 8-3. Cal Raleigh and Rowdy Tellez each went yard for Seattle.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Blue Jays at Astros

• Date: Monday, April 21, 2025
• Time: 8:10PM EST
• Site: Minute Maid Park
• City: Houston, TX
• Network/Streaming: SNI, SCHN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Blue Jays at the Astros

The latest odds as of Monday:

• Moneyline: Blue Jays (+118), Astros (-139)
• Spread:  Astros -1.5
• Total: 7.0 runs

Probable starting pitchers for Blue Jays at Astros

• Pitching matchup for April 21, 2025: Kevin Gausman vs. Hunter Brown
  
  • Blue Jays: Kevin Gausman (2-1, 2.49 ERA)
    Last outing: 4/15 vs. Atlanta - 6IP, 2ER, 6H, 0BB, 6Ks
  • Astros: Hunter Brown (2-1, 1.50 ERA)
    Last outing: 4/15 @ St. Louis - 6IP, 0ER, 4H, 2BB, 4Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Blue Jays at Astros

• The Astros have won 4 of their last 5 home series against the Blue Jays
• Jake Meyers is 8 for his last 18 (.444) and is hitting .305 for the season
• The Astros' last 3 home games with Hunter Brown as the starter have gone under the Total
• Cam Smith is riding a modest 3-game hitting streak (4-11) to raise his avewrage for the season to .232
• The Astros have covered the Run Line in their last 5 games against the Blue Jays

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Blue Jays and the Astros

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday's game between the Blue Jays and the Astros:

• Moneyline: NBC Sports Bet is recommending a play on the Houston Astros on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Toronto Blue Jays at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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