Blue Jays at Astros Prediction: Odds, expert picks, starting pitchers, betting trends and stats for April 23

Its Wednesday, April 23 and the Blue Jays (12-12) are in Houston to take on the Astros (12-11).

Bowden Francis is slated to take the mound for Toronto against Ryan Gusto for Houston.

The Astros have taken the first two games of the series outscoring them 12-1. Last night Christian Walker went 3-3 and drove in a run and Ronel Blanco went 6.2 innings allowing just two hits and one run to earn his second win of the season in a 5-1 Houston victory.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Blue Jays at Astros

• Date: Wednesday, April 23, 2025
• Time: 7:40PM EST
• Site: Minute Maid Park
• City: Houston, TX
• Network/Streaming: SN1, SCHN2, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Blue Jays at the Astros

The latest odds as of Wednesday:

• Moneyline: Blue Jays (-113), Astros (-106)
• Spread:  Blue Jays -1.5
• Total: 8.0 runs

Probable starting pitchers for Blue Jays at Astros

• Pitching matchup for April 23, 2025: Bowden Francis vs. Ryan Gusto
  
  • Blue Jays: Bowden Francis (2-2, 3.13 ERA)
    Last outing: 4/18 vs. Seattle - 6IP, 1ER, 5H, 1BB, 5Ks
  • Astros: Ryan Gusto (2-1, 3.18 ERA)
    Last outing: 4/18 vs. San Diego - 5IP, 2ER, 9H, 0BB, 2Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Blue Jays at Astros

• The Astros have won 5 of their last 7 games, while the Blue Jays have lost 4 of their last 5 on the road
• The Under has cashed in the Astros' last 4 games
• The Blue Jays have failed to cover the Run Line in 4 straight games
• Former Astros' outfielder George Springer is 4-24 (.167) in his last 7 games
• Christian Walker is just 13-64 (.203) in April

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Blue Jays and the Astros

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday's game between the Blue Jays and the Astros:

• Moneyline: NBC Sports Bet is recommending a play on the Houston Astros on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Houston Astros at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)