Cardinals at Reds Prediction: Odds, expert picks, starting pitchers, betting trends and stats for April 28

Its Monday, April 28 and the Cardinals (12-16) are in Cincinnati to take on the Reds (15-13).

Andre Pallante is slated to take the mound for St. Louis against Nick Martinez for Cincinnati.

St. Louis comes to Ohio following a successful weekend at home against Milwaukee. The Cards won two of the three games. They did lose, however, yesterday. Erick Fedde was atrocious yesterday giving up all seven runs in a 7-1 loss in just 5.2 innings. The Reds swept the Rockies in Denver this past weekend. Sunday, they won 8-1. Nick Lodolo threw seven innings of shutout ball to pick up his third win of the season.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Cardinals at Reds

• Date: Monday, April 28, 2025
• Time: 6:40PM EST
• Site: Great American Ball Park
• City: Cincinnati, OH
• Network/Streaming: FDSNMW, FDSNOH, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Cardinals at the Reds

The latest odds as of Monday:

• Moneyline: Cardinals (+104), Reds (-124)
• Spread:  Reds 1.5
• Total: 9.0 runs

Probable starting pitchers for Cardinals at Reds

• Pitching matchup for April 28, 2025: Andre Pallante vs. Nick Martinez
  
  • Cardinals: Andre Pallante (2-1, 4.05 ERA)
    Last outing: 4/22 at Atlanta - 4.1IP, 4ER, 7H, 3BB, 1K
  • Reds: Nick Martinez (0-3, 5.40 ERA)
    Last outing: 4/22 at Miami - 5.2IP, 2ER, 5H, 2BB, 4Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Cardinals at Reds

• The Reds have a winning record (4-1) in their last 5 games
• The Under is 4-1 in the Reds' last 5 games
• The Cardinals have failed to cover the Run Line in 4 straight games
• Cardinals' games have cashed to the UNDER in 3 of their last 4 events
• Elly De La Cruz is riding an 11-game hitting streak (15-44)

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Cardinals and the Reds

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday's game between the Cardinals and the Reds:

• Moneyline: NBC Sports Bet is recommending a play on the Cincinnati Reds on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the St. Louis Cardinals at +1.5.
• Total: NBC Sports Bet is leaning towards a play on the under on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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• Jay Croucher (@croucherJD)
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• Brad Thomas (@MrBradThomas)