Cubs at Diamondbacks prediction: Odds, expert picks, starting pitchers, trends, and stats for March 27

Opening Day for the Cubs and Diamondbacks finds the National League clubs squaring off in Phoenix on Thursday night.

Justin Steele is slated to take the mound for Chicago against Zac Gallen for the Diamondbacks.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Cubs at Diamondbacks

• Date: Thursday, March 27, 2025
• Time: 10:10PM EST
• Site: Chase Field
• City: Phoenix, AZ
• Network/Streaming: MSN, DBACKS.TV

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Cubs at the Diamondbacks

The latest odds as of Wednesday:

• Moneyline: Chicago Cubs (+110), Arizona Diamondbacks (-130)
• Spread: Cubs +1.5 (-190), Diamondbacks -1.5 (+155)
• Total: 8.5 runs

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Probable starting pitchers for Cubs at Diamondbacks

• Thursday’s pitching matchup (March 27): Justin Steele vs. Zac Gallen
  
  • Cubs: Justin Steele
    Spring Training - 1GP, 4.0 IP, 0-1, 11.25 ERA, 5 Ks
  • Diamondbacks: Zac Gallen
    Spring Training - 4GP, 9.1 IP, 2-0, 2.89 ERA, 10 Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Cubs at Diamondbacks

• Prized offseason acquisition Kyle Tucker was just 3-30 (.100) in 13 Spring Training games
• Highly touted 1B Michael Busch was 15-36 (.417) in 14 Spring Training games
• Corbin Carroll hit .400 (18-45) in Spring Training for Arizona
• Corbin Burnes gave up 9 earned runs in 16 IP this Spring

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for Thursday’s game between the Cubs and the Diamondbacks

NBC Sports Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday's game between the Cubs and the Diamondbacks:

• Moneyline: NBC Sports Bet is recommending a play on Arizona on the Moneyline.
• Spread: NBC Sports Bet is recommending a play ATS on the Diamondbacks -1.5.
• Total: NBC Sports Bet is recommending a play on the under on the Game Total of 8.5.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)