Orioles at Nationals Prediction: Odds, expert picks, starting pitchers, betting trends, stats for April 23

It's Wednesday, April 23 and the Orioles (9-13) are in Washington to take on the Nationals (10-13). Tomoyuki Sugano is slated to take the mound for Baltimore against Trevor Williams for Washington.

Washington won the series opener, 7-0, yesterday behind a masterclass from Mitchell Parker and four RBIs from Keibert Ruiz and Nathaniel Lowe. Parker went 8.0 innings with one hit allowed, two walks, and four strikeouts. Cedric Mullins had the lone hit for Baltimore yesterday.

Let's dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Orioles at Nationals

• Date: Wednesday, April 23, 2025
• Time: 6:45PM EST
• Site: Nationals Park
• City: Washington, DC
• Network/Streaming:

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Orioles at the Nationals

The latest odds as of Wednesday:

• Moneyline: Orioles (-138), Nationals (+117)
• Spread:  Orioles -1.5
• Total: 9.0 runs

Probable starting pitchers for Orioles at Nationals

• Pitching matchup for April 23, 2025: Tomoyuki Sugano vs. Trevor Williams
  
  • Orioles: Tomoyuki Sugano, (2-1, 3.43 ERA)
    Last outing: 7.0 Innings Pitched, 2 Earned Runs Allowed, 5 Hits Allowed, 0 Walks, and 3 Strikeouts
  • Nationals: Trevor Williams, (1-2, 5.95 ERA)
    Last outing: 5.0 Innings Pitched, 1 Earned Runs Allowed, 3 Hits Allowed, 3 Walks, and 5 Strikeouts

Expert picks & predictions for tonight’s game between the Orioles and the Nationals

Rotoworld Best Bet

Vaughn Dalzell (@VmoneySports) leans the Orioles ML:

"The Orioles won three straight with Sugano on the mound, while the Nationals have lost three of the four starts for Williams. I have to side with the Orioles, especially after yesterday's disaster for Baltimore (7-0 loss). Sugano is coming off his best start of the season and the O's offense has rallied for five, six, and eight runs in his past three starts."

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday's game between the Orioles and the Nationals:

• Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Washington Nationals at +1.5.
• Total: NBC Sports Bet is leaning towards a play on the over on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Top betting trends & insights to know ahead of Orioles at Nationals

• The Nationals have won 4 of their last 5 home games against teams with losing records
• In the Orioles' last 5 road games the Under is 4-0-1
• The Orioles have failed to cover the Run Line in 5 of their last 7 road games against the Nationals

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!