Orioles at Royals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for April 4

The Baltimore Orioles (3-3) begin a weekend series Friday in Kansas City against the Royals (2-4).

Dean Kremer is slated to take the mound for Baltimore against Seth Lugo for Kansas City

The O's dropped a series earlier this week to the Red Sox. Thursday, Charlie Morton struggled again. The veteran gave up five earned runs in five innings.

KC scored 11 runs to open their series against Milwaukee but proceeded to score just two runs in losing the final two games of the series. Wednesday, they lost 3-2 in 11 innings.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Orioles at Royals

• Date: Friday, April 4, 2025
• Time: 7:40PM EST
• Site: Kauffman Stadium
• City: Kansas City, MO
• Network/Streaming: MASN, FDS

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Orioles at the Royals

The latest odds as of Thursday:

• Moneyline: Orioles (+100), Royals (-120)
• Spread:  Royals 1.5
• Total: 8.0 runs

Probable starting pitchers for Orioles at Royals

• Pitching matchup for April 4, 2025: Dean Kremer vs. Seth Lugo
  
  • Orioles: Dean Kremer (1-0, 8.44 ERA)
    Last outing: 3/29 at Toronto - 5.1 IP, 5ER, 5H, 2BB, 6Ks
  • Royals: Seth Lugo (0-0, 5.40 ERA)
    Last outing: 3/29 vs. Cleveland - 5 IP, 3ER, 4H, 3BB, 4Ks

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Top betting trends & insights to know ahead of Orioles at Royals

• The Orioles have covered the Run Line in each of their wins but have failed to do so in each of their losses
• The Royals' last 3 games against the Orioles have stayed under the Total
• Kansas City is 2-4 on the Run Line this season

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for Friday’s game between the Orioles and the Royals

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday's game between the Orioles and the Royals:

• Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Baltimore Orioles +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)