Orioles at Tigers prediction: Odds, expert picks, starting pitchers, betting trends, and stats for April 25

Its Friday, April 25 and the Orioles (10-14) are in Detroit to take on the Tigers (15-10).

Brandon Young is slated to take the mound for Baltimore against Casey Mize for Detroit.

The Orioles nipped the Washington Nationals on Thursday, 2-1. Cade Povich and three Baltimore relievers allowed one run on just five hits. The Tigers were last in action Wednesday when they shutout the Padres, 6-0. Reese Olson allowed just two hits over 7.1 innings.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Orioles at Tigers

• Date: Friday, April 25, 2025
• Time: 6:40PM EST
• Site: Comerica Park
• City: Detroit, MI
• Network/Streaming: MASN2, FDSNDT, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Orioles at the Tigers

The latest odds as of Friday:

• Moneyline: Orioles (+106), Tigers (-126)
• Spread:  Tigers -1.5
• Total: 8.0 runs

Probable starting pitchers for Orioles at Tigers

• Pitching matchup for April 25, 2025: Brandon Young vs. Casey Mize
  
  • Orioles: Brandon Young (0-0, 6.75 ERA)
    Last outing: 4IP, 3ER, 7H, 3BB, 3Ks
  • Tigers: Casey Mize (3-1, 2.22 ERA)
    Last outing: 4/19 vs. Kansas City - 7IP, 1ER, 4H, 1BB, 3Ks

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Top betting trends & insights to know ahead of Orioles at Tigers

• The Tigers have won 4 of their last 5 games against AL East teams
• Each of the Orioles' last 4 road games with the Tigers have stayed under the Total
• The Orioles have failed to cover the Run Line in their last 4 games and in 5 of their last 6.

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Orioles and the Tigers

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday's game between the Orioles and the Tigers:

• Moneyline: NBC Sports Bet is recommending a play on the Detroit Tigers on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Baltimore Orioles at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)