Phillies at Cubs Prediction: Odds, expert picks, starting pitchers, betting trends and stats for April 25

Its Friday, April 25 and the Phillies (13-12) are in Chicago to take on the Cubs (16-10).

Taijuan Walker is slated to take the mound for Philadelphia against Colin Rea for Chicago.

The Cubs have won four in a row including the last two against the Dodgers. Chicago scored 18 runs in those two games against Los Angeles. Pete Crow-Armstrong belted a couple home runs and drove in seven runs in the two games.

The Phillies arrive in Wrigley having lost three straight to the Mets in New York. Alec Bohm was not the reason the Phillies failed to take any of the three games. The third baseman was 6-12 in the series.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Phillies at Cubs

• Date: Friday, April 25, 2025
• Time: 2:20PM EST
• Site: Wrigley Field
• City: Chicago, IL
• Network/Streaming: NBCSP, MARQ, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Phillies at the Cubs

The latest odds as of Friday:

• Moneyline: Phillies (+113), Cubs (-134)
• Spread:  Cubs -1.5
• Total: 8.0 runs

Probable starting pitchers for Phillies at Cubs

• Pitching matchup for April 25, 2025: Taijuan Walker vs. Colin Rea
  
  • Phillies: Taijuan Walker (1-1, 2.29 ERA)
    Last outing: 4/19 vs. Miami - 4IP, 1ER, 1H, 3BB, 2Ks
  • Cubs: Colin Rea (0-0, 1.32 ERA)
    Last outing: 4/18 vs. Arizona - 4.2IP, 1ER, 5H, 0BB, 5Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Phillies at Cubs

• The Cubs have won 6 of their last 8 games at home, while the Phillies have lost 4 straight
• Each of the Phillies' last 3 games at Wrigley Field have gone over the Total
• The Phillies have failed to cover the Run Line in 4 of their last 5 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for today’s game between the Phillies and the Cubs

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday's game between the Phillies and the Cubs:

• Moneyline: NBC Sports Bet is recommending a play on the Chicago Cubs on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Philadelphia Phillies at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)