Red Sox at Guardians prediction: Odds, expert picks, starting pitchers, trends, and stats for April 25

Its Friday, April 25 and the Red Sox (14-13) are in Cleveland to take on the Guardians (14-10).

Tanner Houck is slated to take the mound for Boston against Ben Lively for Cleveland.

The Red Sox lost Thursday to Seattle, 4-3. Alex Bregman cracked his fifth home run of the season in the loss. Cleveland lost to the Yankees Wednesday but did take two of three from New York earlier this week.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Red Sox at Guardians

• Date: Friday, April 25, 2025
• Time: 7:10PM EST
• Site: Progressive Field
• City: Cleveland, OH
• Network/Streaming: Apple TV+

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Red Sox at the Guardians

The latest odds as of Friday:

• Moneyline: Red Sox (-110), Guardians (-110)
• Spread:  Guardians 1.5
• Total: 9.0 runs

Probable starting pitchers for Red Sox at Guardians

• Pitching matchup for April 25, 2025: Tanner Houck vs. Ben Lively
  
  • Red Sox: Tanner Houck (0-2, 7.66 ERA)
    Last outing: 4/20 vs. White Sox - 6IP, 2ER, 3H, 2BB, 7Ks
  • Guardians: Ben Lively (1-2, 3.86 ERA)
    Last outing: 4/19 at Pittsburgh - 5.1IP, 0ER, 4H, 1BB, 3Ks

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Top betting trends & insights to know ahead of Red Sox at Guardians

• The Guardians are 12-12 on the Run Line this season
• The Red Sox are 13-14 on the Run Line this season
• The Guardians are 7-3 on the Run Line in their last 10 games with a rest advantage

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Red Sox and the Guardians

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday's game between the Red Sox and the Guardians:

• Moneyline: NBC Sports Bet is recommending a play on the Cleveland Guardians on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Guardians at +1.5.
• Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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