Tigers at Astros Prediction: Odds, expert picks, starting pitchers, betting trends and stats for April 28

It's Monday, April 28 and the Tigers (18-10) are in Houston to take on the Astros (14-13). Jack Flaherty is slated to take the mound for Detroit against Ronel Blanco for Houston.

Houston is coming off a 7-3 win over Kansas City that broke a two-game losing streak that featured zero runs scored. Houston is 8-1 when they score at least five runs compared to 6-12 when they do not. Detroit is coming off a three-game series sweep over Baltimore and riding a four-game winning streak. The Tigers held its opponents to zero runs in two of the last four games.

Let's dive into the matchup and find a sweat or two.

Game details & how to watch Tigers at Astros

• Date: Monday, April 28, 2025
• Time: 8:10 PM EST
• Site: Minute Maid Park
• City: Houston, TX
• Network/Streaming: FDSNDT, SCHN2

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Odds for the Tigers at the Astros

The latest odds as of Monday:

• Moneyline: Tigers (-115), Astros (-105)
• Spread:  Tigers -1.5
• Total: 8.0 runs

Probable starting pitchers for the Tigers at Astros

• Pitching matchup for April 28, 2025: Jack Flaherty vs. Ronel Blanco
  
  • Tigers: Jack Flaherty, (1-2, 2.63 ERA)
    Last outing: 6.0 Innings Pitched, 2 Earned Runs Allowed, 5 Hits Allowed, 0 Walks, and 9 Strikeouts
  • Astros: Ronel Blanco, (2-2, 5.01 ERA)
    Last outing: Innings 6.2 Pitched, 1 Earned Runs Allowed, 2 Hits Allowed, 2 Walks, and 3 Strikeouts

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Expert picks & predictions for tonight’s game between the Tigers and the Astros

Rotoworld Best Bet

Vaughn Dalzell (@VmoneySports) leans the Under 8.0 runs between Houston and Detroit:

"While Houston and Detroit are both coming off 7-0 wins yesterday, I'd have to lean the Under between these teams. The Astros offense has been hit or miss over the past week and the Tigers have played low-scoring games all season due to excellent pitching (2.80 ERA, 2nd-best). Houston has seen their pitching succeed with the fourth-best ERA (3.18), so this one is shaping up like a low-scoring affair. I'd look at the Under 8.5 or 8.0 between Detroit and Houston."

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday’s game between the Tigers and the Astros:

• Moneyline: NBC Sports Bet is recommending a play on the Detroit Tigers on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Houston Astros at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Top betting trends & insights to know ahead of Tigers at Astros

• The Tigers have won 4 of their last 5 at AL West teams
• Each of the last 3 matchups between the Astros and the Tigers have stayed under the Total
• The Astros are up 3.58 units on the Run Line in their last 5 at home

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)